Biotechnologický ústav AV ČR

Institute of Biotechnology of the Czech Academy of Sciences announces an open competition in accordance with the Act No. 283/1992 Coll. on the Czech Academy of Sciences, and the Statutes of the Czech Academy of Sciences for a position:

Postdoctoral researcher in metabolism

in the Laboratory of Cellular metabolism, located at the Institute of Biotechnology in BIOCEV. We are a young, international research team that studies metabolism in the context of healthy and tumor tissue, using genetic mouse models, metabolic approaches and omics technologies.

Previously we discovered that quiescent endothelial cells re-wire metabolism to maintain stress resistance and found a major role for oxidative phosphorylation and autophagy in this process (Autophagy, in press). Now we plan to extend these findings and map the metabolism of quiescent endothelium in more detail, to identify molecular mechanisms of metabolic stress resistance in the endothelium with relevance to disease. More details about the laboratory are at: https://www.ibt.cas.cz/en/research/laboratory-of-cellular-metabolism/

Job description:

You will use genetic mouse models and pooled CRISPR screens to search for metabolic pathways that provide oxidative stress resistance in the endothelium. You will oversee your research project but will also function as a part of a team. You will contribute to supervision of junior colleagues, writing of manuscripts, reports and proposals and will present the project results at (inter-)national meetings.

Requirements:

• PhD in biology, biomedicine or related areas
• Publication record in peer-reviewed international journals
• Experience with endothelial biology, metabolism, gene manipulations, omics techniques or mouse models will be considered as an extra advantage
• Excellent communication skills and teamwork, and ability to plan and work independently
• English, written and spoken, advanced level

Institute and workplace location: The Institute of Biotechnology (IBT, ibt.cas.cz) is a top-class multi-disciplinary research center in the Czech Republic with expertise in cancer and developmental biology, metabolism, gene expression and structural biology & protein engineering. IBT is located in the BIOCEV center of excellence (biocev.eu) operated by the Czech Academy of Sciences and Charles University. BIOCEV brings together >500 international scientists and students in >50 research groups. The IBT and BIOCEV partners run excellent core facilities (gene core, chemical synthesis, structural and biophysical analysis, a state-of-the-art animal clinic, flow cytometry & imaging and omics core facilities).

IBT/BIOCEV is in Vestec, located at the outskirts of Prague, ~30 minutes from the city center by public transport.

Application deadline: 28.2.2022

Fully funded position is available immediately. The lab is funded by European (ERC, EMBO, MSCA) as well as national (GACR) sources.

Please send your application including a motivation letter, CV and 2 references to the principal investigator Dr. Jakub Rohlena, jakub.rohlena@ibt.cas.cz where you can also ask for more information.

We hereby inform you that the Institute of Biotechnology of the Czech Academy of Sciences shall process your personal data only to the extent for the purposes of selection of a suitable employee and closure of a contract of employment in accordance with the General Data Protection Regulation 2016/679 (GDPR). 

More details on the processing of personal data of an applicant for open position are available at web site: https://www.ibt.cas.cz/cs/o-ustavu/oficialni-dokumenty/gdpr/.