Biotechnologický ústav AV ČR

Institute of Biotechnology of the Czech Academy of Sciences announces an open competition in accordance with the Act No. 283/1992 Coll. on the Czech Academy of Sciences, and the Statutes of the Czech Academy of Sciences for a position:

Postdoctoral researcher in functional genomics

in the Laboratory of Cellular metabolism, located at the Institute of Biotechnology in BIOCEV. We are a young, international research team that studies the metabolic crosstalk in healthy and tumor tissue using genetic mouse models, functional screens, and single cell omics technologies.

Using these methods, we previously explored the (metabolic) heterogeneity of endothelial cells in pathological angiogenesis (Rohlenova et al. Cell metabolism 2020, Goveia et al. Cancer Cell 2020), and identified new targets for anti-angiogenic strategies. Now, we aim to take a step further to disentangle the network of intercellular metabolic interactions in tissues and tumors that may be a reason for resistance to antimetabolite therapies. More details about the laboratory are at: https://www.ibt.cas.cz/en/research/laboratory-of-cellular-metabolism/

Job description:

You will use genetic mouse models and pooled CRISPR screens to search for new targets that are synthetically lethal with metabolic blockade in cancer. You will oversee your research project but will also function as a part of a team. You will contribute to supervision of junior colleagues, writing of manuscripts, reports and proposals and will present the project results at (inter-)national meetings.

Requirements:

• PhD in biology, biomedicine, bioinformatics, or related areas
• Publication record in peer-reviewed international journals
• Experience with genetic screens, single cell omics or data analysis and programming will be considered as an extra advantage
• Excellent communication skills and teamwork, and ability to plan and work independently
• English, written and spoken, advanced level

Institute and workplace location: The Institute of Biotechnology (IBT, ibt.cas.cz) is a top-class multi-disciplinary research center in the Czech Republic with expertise in cancer and developmental biology, metabolism, gene expression and structural biology & protein engineering. IBT is located in the BIOCEV center of excellence (biocev.eu) operated by the Czech Academy of Sciences and Charles University. BIOCEV brings together >500 international scientists and students in >50 research groups. The IBT and BIOCEV partners run excellent core facilities (gene core, chemical synthesis, structural and biophysical analysis, a state-of-the-art animal clinic, flow cytometry & imaging and omics core facilities).

IBT/BIOCEV is in Vestec, located at the outskirts of Prague, ~30 minutes from the city center by public transport.

Application deadline: 28.2.2022

Fully funded position is available immediately. The lab is funded by European (ERC, EMBO, MSCA) and national (GACR) sources.

Please send your application including a motivation letter, CV and 2 references to Dr. Katerina Rohlenova, katerina.rohlenova@ibt.cas.cz, where you can also ask for more information.

We hereby inform you that the Institute of Biotechnology of the Czech Academy of Sciences shall process your personal data only to the extent for the purposes of selection of a suitable employee and closure of a contract of employment in accordance with the General Data Protection Regulation 2016/679 (GDPR). 

More details on the processing of personal data of an applicant for open position are available at web site: https://www.ibt.cas.cz/cs/o-ustavu/oficialni-dokumenty/gdpr/ .