Full-time offers

Postdoctoral Position(s) in Glioblastoma Biology, Pathogenesis and Genome Instability, at the Danish Cancer Institute

• The Danish Cancer Society is seeking candidates for postdoctoral position(s) in the Genome Integrity Group at the Danish Cancer Institute

About us

• The Danish Cancer Society has its own research centre, consisting of 23 research groups and several core facilities, with around 250 researchers dedicated to basic, translational and epidemiological cancer research, at the internationally highly competitive level.
• The Genome Integrity Group headed by Professor Jiri Bartek focuses on mechanistic understanding of genome stability, cell cycle control, DNA damage response and deregulation of these fundamental processes in cancer development, including discovery of tumor cell-selective stress-tolerance mechanisms that provide cancer cell vulnerabilities targetable by innovative treatments. While this open project will focus on brain tumors and the role of the Human cytomegalovirus in glioblastoma pathogenesis, the group has a broad expertise in diverse human cancer types and fields of cell and molecular biology, signaling, biochemistry, bioinformatics, metabolomics, biomarkers and new treatments including drug repurposing.
• We have discovered several important cell cycle and genome integrity checkpoint pathways and pioneered concepts such as the role of replication stress, G1/S control and DNA damage response in cancer development, often published in recognized journals such as Nature, Science or Cell.
• We have a broad international collaborative network, and the selected candidate(s) will benefit from visits at our collaborating laboratories in Sweden and Finland. For more information, please visit our websites at https://www.cancer.dk/research/

About the position

• The successful candidate will carry out projects focused on the investigation of glioblastoma pathogenesis, particularly the mechanistic basis of the emerging causal role played by the Human Cytomegalovirus in brain cancer development.
• The project will combine the use of cell and molecular biology, signaling, diverse omics approaches including metabolomics, proteomics, DNA and RNA sequencing, high-content microscopy, gene manipulation, virology and cell culture as well as animal models.
• The candidate is expected to closely collaborate with other members of the team and with our collaborators on this project at the Karolinska Institute in Stockholm and University of Turku, participate in scientific conferences, help supervise students and be involved in writing publications.

About you

• We are looking for a highly motivated and enthusiastic candidate with the following qualifications:
  • PhD degree in molecular genetics, cell biology, biochemistry or equivalent from an internationally renowned university or research center
  • Excellent technical skills and strong experience with molecular, biochemical and cell biology-based techniques, especially microscopy, gene manipulation, cell culture and cancer biology;
  • Documented experience in glioblastoma pathobiology, brain research and work with the viruses, especially the Human Cytomegalovirus would be a significant advantage.
  • A strong publication profile related to the areas of cancer biology, genome (in)stability and role of viruses, metabolic rewiring in cancer pathogenesis are expected
  • Familiarity with virology, coding and omics dataset analysis is an advantage
  • Experience in student supervision and project management is welcome
  • Excellent oral and written communication skills in English

We offer

• We offer creative and stimulating working conditions in a dynamic international research environment with an inclusive and collaborative working culture.
• Our laboratories are equipped with modern interior and state-of-the-art technology, located in a pleasant and beautiful area near central Copenhagen.
• You will join a stimulating working atmosphere, with weekly seminars, invited speakers, a young researcher association, as well as strong administrative and technical support.
• We offer several benefits for the personnel, such as an excellent canteen, a daily selection of free fruit, and sport activities. Working hours are of course smoke-free.
• The everyday working language in the team is English.
• The recently renovated laboratories are equipped with state-of-the-art instruments.
• Core facilities at the Research Institute, including: Level P2 laboratory for work with viruses, Bioimaging, Lipidomics/metabolomics, Flow cytometry/cell sorting, Bioinformatics, CRISPR/ gene editing and chemical-biology high-throughput screening facilities, nucleic acid sequencing, histology laboratory and animal house facility are available to all employees. 
• We have be-weekly seminars, hands-on workshops, international speakers and Young Researchers Association.
• Benefits for employees include health-conscious canteen, free fruit and sport activities. The everyday working language is English and the Center is smoke-free.

Working conditions:

• 37.5 hours a week with lunch break included.
• A competitive salary with a range of benefits will be provided according to the current agreements between the Danish Cancer Society and the relevant trade union.
• Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark in the last 10 years.

Additional information

• More information can be obtained directly from the group leader Professor Jiri Bartek jb@cancer.dk

Application and closing date for applications

• The deadline for application is May 10th, 2025. Selected candidates will be invited for an interview.
• The position is available from June 1st, 2025 or as soon after that date as possible (negotiable) for the duration of 2 years with a possibility of extension for up to additional 2 years.

The application should be written in English and must be submitted electronically through our website: www.cancer.dk/om-os/stillinger, via the link 'Apply for position'.

The application should contain:

• A CV, including description of research-related skills and a list of publications
• A motivation letter
• A copy of the PhD and MSc diploma (or expected date of obtaining a PhD diploma if not finished yet)
• Names and contact information of two-three scientists from previous working place(s) as a reference
• https://candidate.hr-manager.net/ApplicationInit.aspx?cid=1572&ProjectId=145488&DepartmentId=18958&MediaId=5&SkipAdvertisement=False

Ph.D. student in the Laboratory of Biophysics

• Are you passionate about cutting-edge biophysical research? Join the Laboratory of Biophysics at the Department of Optical and Biophysical Systems, Institute of Physics of the Czech Academy of Sciences! We are dedicated to unraveling how physical factors, such as novel nanomaterials and mechanical forces within the cell microenvironment, impact cellular machinery.

• Our current research focuses on “The impact of extracellular mechanical cues on interactions between DNA nanostructures and hepatic cells.” DNA nanotechnology has revolutionized the creation of novel composite materials with diverse applications in biomedicine. To bridge the gap between these innovations and their real-world applications, it is crucial to understand how DNA nanostructures interact with living cells and the subsequent effects of these interactions. Our goal is to explore the molecular and biophysical mechanisms that influence the uptake and processing of DNA nanostructures by cells under external mechanical forces. We will investigate the cellular processing of these nanostructures, including their transport mechanisms, organelle interactions, and degradation pathways.

• We invite enthusiastic students to join our dynamic team. Whether you're at the beginning of your academic journey or further along, we offer a rich learning experience tailored to your level of expertise.

What you will do

• Engage in cell culturing, characterization, and analysis of cell lines
• Set up and conduct experimental work to explore exciting scientific questions in modern biophysics)

Required qualifications

• Pursuing a degree in cell biology, biochemistry, biology, or a related discipline (junior or senior standing)
• Possess strong analytical and problem-solving skills
• Capable of delivering on project timelines, both independently and in team settings
• Effective communicators, both verbally and in writing

What we can offer

• We are committed to providing a stimulating and supportive environment.

Here’s what you can expect:

• Learning Opportunities:
  • Gain hands-on experience with advanced laboratory techniques and methods, including:
    • Conventional confocal and super-resolution live cell imaging
    • Cell culturing
    • Cytotoxicity studies
    • Cell signaling analysis
    • Protein function analysis
    • Gene editing and expression analysis
• International and Friendly Environment:
  • Join a diverse team of researchers in a well-equipped lab with state-of-the-art facilities
• Professional Growth:
  • Develop your analytical and problem-solving skills while working on impactful projects
• Excellent PhD Program:
  • Student will be appointed to “Biochemistry and Pathobiochemistry” PhD program at the 1st Faculty of Medicine of the Charles University, Prague

It´s good to know

• Start of employment as soon as possible, depending on the availability of the applicant
• Full-time job with flexible hours, extended vacations, work from home, and a wide range of other benefits
• 1-year contract with possible extension
• Interested candidates are invited to apply by sending a CV and a motivation letter, including a publication record to kariera@fzu.cz
• For further information please contact HR partner Petra Kratochvílová +420 607240074

We look forward to hearing from you!

• FZU – Institute of Physics of the Academy of Sciences of the Czech Republic is a leading public research institution based in Prague. FZU is the largest institute of the Academy of Sciences of the Czech Republic with more than 1100 employees and focuses on basic and applied research in the field of physics. Our top researchers strive to understand and explain the basic phenomena and processes of how the world works and thus respond to the current scientific and technical challenges of our society.

• As an employer, FZU supports equal opportunities and diversity. This approach helps to foster a positive work culture and creates a supportive environment for all employees. The principles of diversity, equity, and inclusion are embedded in our policies and hiring practices, providing a solid foundation for fair selection processes.

GDPR – protection of your personal data

• We would like to inform you that by sending a reply to the advertisement, you provide the relevant administrator with your personal data for the purpose of conducting the selection procedure and concluding an employment contract or agreement (DPP, DPC) regarding the position you have chosen. This processing of your personal data will be carried out on the legal basis of the performance of a contract pursuant to Article 6 para. 1 lit. b) the General Data Protection Regulation (GDPR). Your personal data will be processed only to the extent necessary and only for the duration of the selection procedure for the given position. The processing of your personal data will be sufficiently secured, your personal data will not be passed on to third parties without your consent. In accordance with applicable law, we inform you that you have the right to (i) access your personal data, (ii) correct or complete inaccurate or false personal data, (iii) to erasure of personal data, (iv) to restrict the processing of personal data in special cases, (v) to data portability, (vi) to object to processing and (vii) to contact the Office for Personal Data Protection. 

We are looking for researchers in the following fields:

Candidates will have to apply and pass a series of tests to be recruited. The open competition is managed by EU Careers by EPSO.

On November 5 we will post a link to the new dedicated webpage, with detailed information on how to apply. Stay tuned!